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August 27, 2013


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Consuming 28 cups of coffee weekly meaning one has to drink 4 cups of coffee daily. I am a coffee lover but consuming that much in a day is still quite a bit. But I agree with the author that consuming this much would not benefit. Anything with moderation is beneficial and harmful if overdose.

This is an interesting finding; however I am still confused about the mechanism of action of chlorogenic acid. This article lists chlorogenic acid as a component of coffee which produces many health benefits; although it has been my understanding that consumption of chlorogenic acid leads to elevated homocysteine levels which has directly damages the arterial wall, promotes oxidation and inflammation.

A major factor is overlooked here: This is a study of people who choose to drink coffee vs. those who chose not to do so. It is not necessarily abouot the coffee at all, but about personality types, lifestyle choices, etc. Until a real study can be done where folks who want to drink coffee are randomized into those allowed and those given placebo, and folks who have no desire for coffee are randomized into two similar arm, we will not be truly observing the effects of coffee on people, but of what occurs in people who make specific lifestyle choices.

Is it coffee or just caffeine that increases risk of death at high enough doses? I know caffeine supplementation is used sometimes at very high levels of athletics so maybe precautionary information should be made available.

Large longitudinal studies such as the one presented here may not be entirely appropriate for determining causal relationships, as many confounders may occur. There are many things to consider before drawing a conclusion: are individuals of a particular lifestyle (i.e. more demanding career, more stress; a lifestyle that will have a negative impact on overall health) more likely to consume large amounts of coffee? Were there geographically-related health concerns in the study population? Were disease states/illnesses that may cause fatigue and subsequently lead to increased caffeine consumption identified and controlled for? Ongoing studies of coffee/caffeine consumption by the Harvard School of Public Health have attributed many positive health outcomes to moderate coffee consumption (realize that four to five cups of coffee per day as stated in this blog should not be considered moderate). Recently, the School publicized findings that drinking coffee may be linked to a significantly lower risk of suicide.

The consumption of coffee and exposure to long term caffeine levels has always been a hotly debated topic. I have always had the stance that high levels of a product such as caffeine that increases heart rate cannot be good to consume in a chronic manner. I believe it may be similar to the way high blood pressure increases the rate atherosclerosis.

This seems like a very interesting and potentially controversial study. I wonder if the study took into effect what was being consumed with the coffee (sugar, creamer, milk, etc.) when doing their analysis. To me this would have a huge effect on a person's lifestyle, especially if they were drinking 4+ cups of coffee a day. Thankfully I've always enjoyed my coffee black and this study gives me more of a reason to do so!

This was a very interesting article to read, especially considering the large number of people that consumes coffee on a daily basis. I would like to see what baseline characteristics these study participants have. 28 cups a coffee per week, which equates to average 4 cups a day, which also equals to about a large and a medium at your Starbucks or Dunkin. The amount of sugar is enough to put the average person at risk for other cardiovascular/diabetic associated problems. It would be interesting to see how old the patients are and what the causes of death were.

I don't know if it's fair to assume that people who drink a lot of coffee (not sure either how much is considered too much) get less sleep than others. Not having enough sleep is a part of an unhealthy lifestyle too, which in turn, could contribute to increased death risk in that way. To repeat what's being said in a lot of the comments, finding the right amount of coffee consumption is the key.

As a coffee lover, I am a little disappointed to see coffee associated with increased risk of death. However, I feel this information should be taken with a grain of salt. I believe there are many other factors to be taken into account. There could be many confounding factors causing increased death, so it is difficult to make the direct link between coffee and death. Also, although I love coffee, I never find myself drinking at least 4 cups a day, so according to data from this study this risk may not be appropriately extrapolated to people who consumer smaller amounts of coffee per day.

As others commented previously, I feel as though moderation is key. When looking at this study it seems as though there are too many variability’s to form a correlation between coffee and increased mortality. I think it would be important in this case to consider the study population’s lifestyle. I know I can’t drink more then a cup of coffee a day. The population studied may have a high stress lifestyle, which may contribute to the increase in mortality rate. I also think its important to specify the type of coffee that is being consumed and if there are other factors other then caffeine that may explain why this correlation is seen.

Mollie's comment is very fascinating "live fast, die young". It would be a very interesting study to see the effects coffee has on metabolism and body aging processes. Could coffee effect the genetic processes involved in aging? It would be an amazing study to conduct and see the results of.

It morning as I pondered making my first pot of coffee, and then I came across this article! An interesting problem with the coffee studies, the is conflict in how the coffee is drank. Many people use cream and sugar while others drink it black. Sugar and cream contain many excess calories, and these can add up quickly if your drinking several cups a day. I also think it would be interesting to study decaf coffee as well. This may help better understand the role of caffeine plays in the analysis of coffee safety and efficacy.

It's interesting to see this blog post and also see conflicting information in the news. Some say moderation is not only not harmful, but also beneficial. I think it had to do with cardiovascular health maybe, but I'm not sure. We actually had an elective last quarter called Coffee and Health. I didn't take it, but it's obvious that coffee seems to be a hot topic across the board these days.

Couldn't help but to comment on this one! Surveys and interviews aren’t the best way to collect data but still could be reliable. I would like to know the baseline characteristics for this study and if the participants already had an elevated risk for cardiovascular outcomes. What were the other causes of death? Either way, 28 cups of coffee a week is quite a bit, that’s four cups per day, which doesn’t seem too healthy to begin with! However, I’m sure plenty of people do it. I’d like to see this information in other types of caffeinated beverages as well. Can’t live without my energy drinks and sodas!

An article published in Science Daily on April 25, 2013 reports that coffee may help prevent breast cancer recurrence. This study conducted in South Sweden noted that participants taking Tamoxifen and two or more cups of coffee daily showed a reduction in the recurrence of breast tumor. The Lund University researchers also reported previously that coffee intake minimize the risk of certain types of breast cancer. It also decrease the growth of cancer cells. The South Sweden researchers need to make the number of cups of coffee per day more specific because more coffee could mean three or 28 cups of coffee. If the number of cups get to 28 per day, does this mean the patients are now at an increased risk of death?

Maybe there is something to the old adage "live fast, die young." Perhaps the stimulant effects of coffee are increasing body-wide metabolism and changing the rate of aging.

It would have been nice to have had full access to the above article. I'm unsure of what exactly all cause death means and how it may correlate to coffee by only being able to read the abstract. Even though this is a large number of participants I think more research is certainly needed before we can assume that drinking coffee can increase a person’s risk of death.

This just goes to show all things are good in moderation. It would good to compared baseline characteristics of this trials and those that part took in the trial from before. It would also be interesting to look at the follow up period of those in the original trial that stated coffee was beneficial. I would assume that the necessity to drink over an average of 4 cups of coffee a day multiple other complications would arise.

I think we need further studies and quality data to assume that coffee is a cause of death. Additionally, this study has potential association with no causation and effect relationship. On the contrary, there have been studies, which have shown a cause and effect relationship with coffee to be beneficial in many aspects of health care. Thus, I would not make a recommendation based on this study.

An article posted earlier stated how caffeine is good for mental stimulation and short term memory, however this study shows that we really do need to drink caffeine in moderation. I know that when I drink too much caffeine or coffee my heart races, therefore I can't comprehend how fast it would beat if I were to drink 4-5 cups a day! I can see where that would definitely have health consequences. Just like all things, moderation is the key.

I'd be interested to also see baseline characteristics for the participants in this study, and if the subjects were consuming any other caffeine related products such as red bull, monster, and or other energy drinks in addition to the already high amounts of caffeine from the coffee they are consuming. That could possibly serve as confounding factors. Like Austin said, caffeine seems to be going up in down in terms of good or bad - but as always, everything in moderation is best!

I would be very interested to see what other factors were involved in these patients. Such as other disease states, medications, lifestyles, etc. It would be interesting to see, because it seems to me that these results may be skewed. Especially if you think about how much coffee four cups actually is. Based on what we have all learned 8 ounces is one cup, that being said 4 cups a day is only about 32 ounces, and if you know that the average coffee mug is about 16 ounces, It is not all that impossible to think that most americans drink at least 2 or 3 of those a day. I would be interested to see more detailed results of this study.

There have been many studies claiming the health benefits of coffee such as lowering blood sugar levels and improving cognitive function. There are also studies on how red wine and beer consumption provide cardioprotective functions. Although the health benefits are highlighted in these studies, it is important to understand the bottom line message. Excess amounts coffee, red wine or beer can lead to detrimental effects. Moderation is key.

Although cohort studies can be useful for discovering possible associations, I'm wondering how explorable further more defined studies on this topic would be because of the amount of time and number of patients that would be needed to show a substantial effect. Like Austin stated before, this topic of discussion seems to go back and forth and I think efforts may be better spent trying to further detail the extent of the current health risks we know caffeine can cause.

I couldn't access the full article, but I'd be interested to see the baseline characteristics of subjects in this study and compare it to the baseline characteristics of the subjects in the 2012 study that said there was a reduced risk of death associated with coffee consumption. I'm curious to see if there was some confounding factor that may have lead to the results (increased risk of death) in this most recent study.

Although coffee has been linked to lowering blood sugar, too much coffee may not be a good thing. Many nutritious foods have their limits and it is important not to over do it. It would be interesting to see if the causes of death in the participants under fifty-five were hypertension linked mortalities. Greater than twenty-eight cups of coffee is more than 4 cups a day which is a significant amount of coffee. If participants were only drinking 2 cups a day, would a correlation still be seen?

I often see caffeine go back and forth on its effects on health. I think it might be a matter of finding the right balance due to huge amount of variation in coffee consumption in these studies. I'd say four cups of coffee a day does seem a little excessive, however, as caffeine does have a number of documented adverse effects. Of them, affecting cortisol and blood pressure levels may have a link towards the increase in mortality seen here.

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